In vivo evaluation of antidiarrhoeal activity of ethanolic extract of leaf and bark of Ficus carica Linn.

Ficus carica Linn

Ashraf-ul Kabir, Ninadh Malrina D’Costa, Mehdi Bin Samad, JMA Hannan

Key words: Antidiarrhoeal, castor oil, enteropooling, Ficus carica Linn, prostaglandin E2.

Abstract

Ficus carica Linn is occasionally used in preparation of local traditional medicines used in the treatment of diarrhoea in Bangladesh. Our present studies make an attempt toward validating this traditional use by investigating antidiarrhoeal activity of F. carica Linn. Ethanolic extract of leaf and bark of F. carica Linn showed significant (p ≤ 0.05) decrease in the severity of diarrhoea, in a dose dependent manner, in castor oil induced diarrhoea test. Prostaglandin E2 induced intestinal fluid accumulation test (enteropooling) gave significant results (P ≤ 0.05), indicating possible antidiarrhoeal action. The extract produced significant (P ≤ 0.05) reduction of intestinal transit in gastrointestinal motility test with barium sulfate milk in healthy rats. It is evident that F. carica Linn have significant antidiarrhoeal activity and may be a potential source of antidiarrhoeal agents.

Read full Article: Volume 2, Number 3, November 2012 – IJBB

Published on: International Journal of Biomolecules and Biomedicine (IJBB)

Advertisements

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s