Biochemical and histological changes associated with methanolic leaf extract of Gongronema latifolium in acetaminophen-induced hepatic toxicity in wistar albino rats

biochemical

Biochemical and histological changes associated with methanolic leaf extract of Gongronema latifolium in acetaminophen-induced hepatic toxicity in wistar albino rats

Chinedu Imo, Friday O. Uhegbu, Ifeanacho Nkeiruka G., Egbeigwe Otito, Ezekwe A. S

Key words: Acetaminophen, biochemical, Gongronema latifolium, histological changes.

Abstract:

This study examined the biochemical and histological changes associated with methanolic leaf extract of Gongronema latifolium in acetaminophen-induced hepatic toxicity in wistar albino rats. The serum liver enzymes ALT, AST and ALP decreased significantly (p<0.05) in the test animals treated with 600mg/kg of the leaf extract. Protein concentration increased significantly (p<0.05) in the test animals treated with 600mg/kg of the leaf extract.The effect of the G. latifolium leaf extract seems to be dose dependent on the liver enzymes and protein concentration measured. The results showed that acetaminophen-induced hepatic toxicity in the wistar albino rats as observed in the negative control was reversed with the administration of the leaf extract of Gongronema latifolium (in groups 3, 4 and 5) in the test animals. The histological analysis of the liver showed that the extract had a normalising effect on the effected liver. These results indicate that the leaf extract of Gongronema latifolium exhibits biochemical and histological changes and can be used against some hepatic inflammations.

Article Source: Volume 4, Number 2, February 2014 – IJBB

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